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Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus.
Pack Size | Price | Availability | Quantity |
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2 mg | $48 | 5 days |
Description | Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus. |
In vitro | Bz-423 triggers the activation of Bax and Bak without concurrently activating ASK1/JNK in Ramos cells[2]. The induction of apoptosis by Bz-423 in Ramos cells relies on superoxide, and it elicits a heightened superoxide response in these cells, resulting in the swift demise of Ramos B cells. In MEFs, Bz-423 rapidly elevates superoxide levels within 1 hour, with the extent of the increase depending on the concentration. In Ramos cells, Bz-423-induced superoxide generation instigates the activation of Bax and Bak, mediated by alterations in Mcl-1 expression and the functional activation of BH3-only proteins[1]. |
Alias | BZ48 |
Molecular Weight | 440.92 |
Formula | C27H21ClN2O2 |
Cas No. | 216691-95-1 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (181.44 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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