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Bz 423

Bz 423
Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus.
Catalog No. T14846Cas No. 216691-95-1
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Purity:98.89%
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Bz 423

Purity: 98.89%
Catalog No. T14846Alias BZ48Cas No. 216691-95-1

Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus.
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2 mg$485 days
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Product Introduction

Bioactivity
Description
Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus.
In vitro
Bz-423 triggers the activation of Bax and Bak without concurrently activating ASK1/JNK in Ramos cells[2]. The induction of apoptosis by Bz-423 in Ramos cells relies on superoxide, and it elicits a heightened superoxide response in these cells, resulting in the swift demise of Ramos B cells. In MEFs, Bz-423 rapidly elevates superoxide levels within 1 hour, with the extent of the increase depending on the concentration. In Ramos cells, Bz-423-induced superoxide generation instigates the activation of Bax and Bak, mediated by alterations in Mcl-1 expression and the functional activation of BH3-only proteins[1].
AliasBZ48
Chemical Properties
Molecular Weight440.92
FormulaC27H21ClN2O2
Cas No.216691-95-1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (181.44 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2680 mL11.3399 mL22.6799 mL113.3993 mL
5 mM0.4536 mL2.2680 mL4.5360 mL22.6799 mL
10 mM0.2268 mL1.1340 mL2.2680 mL11.3399 mL
20 mM0.1134 mL0.5670 mL1.1340 mL5.6700 mL
50 mM0.0454 mL0.2268 mL0.4536 mL2.2680 mL
100 mM0.0227 mL0.1134 mL0.2268 mL1.1340 mL

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